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Since cefuroxime is primarily eliminated by the kidney, the presence of hepatic dysfunction is expected to have no effect on the pharmacokinetics of cefuroxime. Method of administration Cefuroxime axetil tablets should be taken buy food for cefuroxime absorption. Patients with known hypersensitivity to cephalosporin antibiotics. History of severe hypersensitivity e, buy cefuroxime 250mg. As with cefuroxime beta-lactam antibacterial agents, serious and occasionally fatal hypersensitivity reactions have been reported, buy cefuroxime 250mg.
In case of severe hypersensitivity reactions, treatment with buy must be discontinued immediately and adequate emergency measures must be initiated. Before beginning treatment, it should be established whether the patient has a history of severe hypersensitivity reactions to cefuroxime, to other cephalosporins or to 250mg other type of beta-lactam agent.
Caution should be used if cefuroxime is given to 250mg with a history of non-severe hypersensitivity to other beta-lactam agents.
Jarisch-Herxheimer reaction The Jarisch-Herxheimer reaction has been seen cefuroxime cefuroxime axetil treatment of Lyme disease. It results directly from the buy activity of cefuroxime axetil on the causative 250mg of Lyme disease, the spirochaete Borrelia burgdorferi, buy cefuroxime 250mg.
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Patients should be reassured that this is a common and usually self-limiting consequence of antibiotic treatment of Lyme disease see section 4. Overgrowth of non-susceptible microorganisms As with other antibiotics, use of cefuroxime axetil may result in the overgrowth of Candida. Prolonged use may also result in the overgrowth of other non-susceptible microorganisms e. Antibacterial agent—associated pseudomembranous colitis have been reported with nearly all antibacterial agents, including cefuroxime and may range in severity from mild to life threatening, buy cefuroxime 250mg.
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This diagnosis should be considered in patients with diarrhoea during or subsequent to the administration of cefuroxime see section 4. Discontinuation of therapy with cefuroxime and the administration of specific treatment for Clostridium difficile should be considered. Medicinal products that buy peristalsis should fluconazole tableta 150mg be given see section 4.
Interference with diagnostic tests The development of a positive Coomb's Test associated with the use of cefuroxime cefuroxime interfere with cross matching of blood see section 4. Important information about excipients Special care should be taken with phenylketonuric patients because of the 250mg containing coating, buy cefuroxime 250mg.
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Cefuroxime axetil mg coated tablets contain 0. Cefuroxime is excreted by glomerular filtration and tubular secretion. Concomitant use of probenecid is not recommended, buy cefuroxime 250mg. Concurrent administration of probenecid significantly increases the peak concentration, area under the serum buy time curve and elimination half-life of cefuroxime.
Concomitant use with oral anticoagulants may give rise to increased INR. Studies in animals have shown no harmful effects on pregnancy, embryonal or foetal development, parturition or postnatal development. Cefuroxime cefuroxime should be prescribed to pregnant women only if the benefit outweighs the risk.
Breastfeeding Cefuroxime is excreted in human milk 250mg small quantities, buy cefuroxime 250mg.
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Adverse effects at therapeutic doses are not expected, although a risk of diarrhoea and fungus infection of the mucous membranes cannot be excluded. Breastfeeding might have to be discontinued due to these effects.
The possibility of sensitisation should be taken into account. Fertility There are no data on the effects of cefuroxime axetil on fertility in humans. Reproductive studies in animals have shown no effects cefuroxime fertility. However, as this medicine may cause dizziness, patients should be warned to be cautious when driving or operating machinery. The frequency categories assigned to the adverse reactions below are estimates, as for most reactions suitable data for example from placebo-controlled studies for calculating incidence were not available.
In addition the incidence of adverse reactions 250mg with cefuroxime axetil may vary according to the indication. Data from large clinical studies were used to determine the frequency of very common to rare undesirable effects. The frequencies assigned to all other undesirable effects i. Placebo-controlled trial data were not available. Where incidences have been calculated from clinical trial data, these were based on drug-related investigator assessed data.
Within each frequency grouping, buy cefuroxime 250mg, undesirable effects are buy in order of decreasing seriousness. Treatment related adverse reactions, all grades, buy cefuroxime 250mg, are listed below by MedDRA body system organ class, frequency and grade of severity. The following convention has been utilised for the classification of frequency: