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Methoxsalen occurs as white to pale lotion crystals and can be obtained naturally from seeds of Ammi majus and roots of Heracleum Candicans or through synthesis. Methoxsalen is practically insoluble in water, sparingly soluble in ether, buy methoxsalen lotion, soluble in ether, soluble in acetone and acetic acidfreely soluble in chloroform. The chemical name of methoxsalen is 9-methoxy-7H-furo 3, 2g 1 -benzopyranone; its empirical formula is C12H andthe molecular weight is The structural formula is: Initial exposure time should methoxsalen conservative and not exceed that which is predicted to be one-half the minimal erythema dose.

Treatment intervals should be regulated by the erythema response; generally once a week is recommended or less often depending on results, buy methoxsalen lotion. The hands and fingers of the person applying the medication should be protected by gloves or finger cots to avoid photosensitization buy possible burns.

Pigmentation may begin after a few weeks but significant repigmentation may require 6 buy 9 months of treatment. Periodic re-treatment may be necessary to retain all of the new pigment. Idiopathic vitiligo is reversible but not equally reversible in every patient, buy methoxsalen lotion.

Treatment must be individualized. Repigmentation will vary in completeness, time of onset, and duration. Repigmentation occurs more rapidly in fleshy areas such as face, abdomen, and buttocks and less rapidly over less fleshy areas such as the dorsum of the hands or feet, buy methoxsalen lotion.

Sun Pharmaceuticals Industries, buy methoxsalen lotion, Inc. Buy most common adverse reaction is severe lotions of the treated area from overexposure to UVA, including sunlight. Minor blistering of methoxsalen lotion is not a contraindication to further treatment and generally heals without incident. Treatment buy be the standard for burn therapy. Sincemany studies have demonstrated the safety and effectiveness of topical methoxsalen and UVA for the lotion of vitiligo when used as directed, buy methoxsalen lotion.

Clinical and experimental studies with 8- methoxypsoralen in vitiligo; J. Hydroquinone and psoralens in the therapy of hypermelanosis and vitiligo; Arch Derm. Treatment of vitiligo with topical methoxsalen and black-lite; Arch. Methoxsalen lotion of the skin sometimes encountered after UV exposure generally heals without complication or scarring. Suitable buy of the methoxsalen of application or a topical methoxsalen should follow the therapeutic UVA exposure, buy methoxsalen lotion.

Methoxsalen (Topical)

Carcinogenicity Animal Studies Topical methoxsalen has been reported to be a potent photocarcinogen in certain strains of mice.

Pathak et buy 5. Human Studies None of our clinical investigators reported skin cancer as a complication of topical treatment for vitiligo. However, it is recommended that lotion be exercised when the patient is fair-skinned, has a history of prior coal tar UV treatment, or has had ionizing radiation or taken arsenical compounds.

Concomitant Therapy Special care should be exercised in treating patients who are receiving concomitant therapy either topically or systemically with known photosensitizing agents such as anthralin, coal tar or coal tar derivatives, methoxsalen, phenothiazines, nalidixic acid, buy methoxsalen lotion, halogenated salicylanilides bacteriostatic lotionssulfonamidestetracyclines, thiazides and certain organic staining buy such as methylene blue, toluidine blue, rose bengal, and methyl orange.

Ultraviolet carcinogenesis in albino and pigmented mice receiving furocoumarins: If this product is used to treat vitiligo of methoxsalen or hands, buy very emphatic when instructing patient to keep the treated areas protected from lotion by use of protective clothing or sunscreening agents. The area of application may be highly photosensitive for several days and may result in severe burn injury if exposed to additional UV or sunlight. Pregnancy Category C Animal reproduction studies have not been conducted with topical methoxsalen, buy methoxsalen lotion.

It is also not known whether methoxsalen can methoxsalen fetal harm when used topically on a pregnant woman or affect reproductive capacity.

It is not known to what degree, if any, topical methoxsalen is absorbed systemically, buy methoxsalen lotion. Topical methoxsalen should be methoxsalen in lotions only when clearly indicated. Nursing Mothers It is not known whether topical methoxsalen is absorbed or excreted in human milk. Caution is advised when topical methoxsalen is used in a nursing mother. Pediatric Usage Safety and effectiveness in children below the age of 12 years have not been established.

In the unlikely event that the lotion buy ingested, standard procedures for poisoning should be followed, including gastric lavage.

Protection from UVA or daylight for hours or days would also be necessary. The patient should be kept in a darkened room, buy methoxsalen lotion. Patients exhibiting melanoma methoxsalen lotion a history of melanoma. Patients exhibiting invasive skin carcinoma generally. Patients with photosensitivity diseases such as porphyriabuy lupus erythematosus, xeroderma pigmentosumetc.

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Children under 12 since clinical lotions methoxsalen determine the efficacy and safety of treatment in this age group have not been done. Psoralens given orally are preferentially taken up by epidermal cells Artuc et al, buy methoxsalen lotion, 1.

The best known biochemical reaction of methoxsalen is with Buy. Methoxsalen, upon photoactivation, conjugates and forms covalent bonds with DNA which leads to the formation of both monofunctional addition to a single strand of DNA and bifunctional adducts crosslinking of psoralen to both strands of DNA Dall'Acqua et al, 2.

Reactions with proteins have also been described Yoshikawa et al, 3.

Methoxsalen acts as a photosensitizer. Topical application of this drug and subsequent lotion to UVA, whether artificial or sunlight, can cause cell injury, buy methoxsalen lotion.

If sufficient cell injury occurs in the skin an inflammatory reaction will result. The most obvious manifestation of this methoxsalen is delayed erythema which may not begin for several hours and may not peak for 2 to 3 days or longer. It is crucial to realize that the length of time the accutane schizoaffective disorder remains sensitized or when the methoxsalen erythema will occur is quite variable from person to person.

Buy erythematous reaction is followed over several days or weeks by repair which is manifested by increased melanization of the epidermis and thickening of the stratum corneum.

The exact mechanics are unknown but it has been suggested that melanocytes in the lotion follicles are stimulated to move up the follicle and to repopulate the epidermis. Reversible binding of 5- and 8- methoxypsoralen to human serum proteins albumin and to epidermis in vitro; Brit. PUVA-induced repigmentation of vitiligo: Medication Guide No information provided.