Tramadol dosismg/kg

This information is intended for use by health professionals 1. Qualitative and quantitative composition Each tramadol contains 50mg Tramadol hydrochloride For the full list of excipients, see dosismg/kg 6. Clinical particulars The treatment of moderate to severe pain, tramadol dosismg/kg. The lowest effective dose for analgesia should generally be selected, tramadol dosismg/kg. Adults and children over 12 years Acute pain: Adults and children over age 12 years: Patients with low weight should use 0.

Duration of therapy depends upon clinical need. An initial dose of 50mg tramadol mg is dosismg/kg by doses of 50mg or mg, every 4 to 6 hours, according to pain severity. The need for continued treatment should be assessed at regular intervals as dosismg/kg symptoms and dependence have been reported.

A total daily tramadol of mg should not be exceeded.

Tramadol 50mg/ml Solution for Injection or Infusion

Tramadol should under no circumstances be administered for longer than absolutely necessary. If long-term pain treatment with tramadol is necessary in view of the nature tramadol severity of the illness, then careful tramadol regular monitoring should be carried out if necessary with dosismg/kg in treatment to establish whether and to what extent further treatment is necessary. Older people A dose cheap simvastatin 80mg price is not usually necessary in patients up to 75 years dosismg/kg clinically manifest hepatic or renal insufficiency.

In elderly patients over tramadol years elimination may be prolonged, tramadol dosismg/kg. Therefore, if necessary the dosage dosismg/kg is to tramadol extended according to tramadol patient's requirements. The usual initial dosage should be used. In these patients prolongation dosismg/kg the dosage intervals should be carefully considered according to the patient's requirements.

Tramadol is removed very slowly by haemodialysis or haemofiltration tramadol post-dialysis administration to maintain analgesia is not usually necessary, tramadol dosismg/kg. Patients with hepatic impairment The elimination of tramadol may be prolonged, tramadol dosismg/kg. Dosismg/kg usual dosage should be divided in 2, or the dosage interval should be extended to 12 hours, tramadol dosismg/kg.

In severe hepatic impairment, tramadol dosismg/kg, the product is contraindicated. Paediatric dosismg/kg Children under 12 years: Tramadol of administration The capsules are taken orally, tramadol of meals, tramadol whole with water 4. At therapeutic doses tramadol has the potential to cause withdrawal symptoms. A reporting frequency of 1 in has been stated, tramadol dosismg/kg. Reports of these are dosismg/kg and less frequent than withdrawal reactions, tramadol dosismg/kg.

The dosismg/kg need for analgesic treatment should be dosismg/kg regularly. On long-term use dosismg/kg, psychic and physical dependence may develop. Tramadol patients with a tendency to drug abuse or dependence. Treatment should only be for short periods and under medical supervision.

Tramadol Preguntas ....

Tramadol is not suitable as a substitute in these patients and cannot suppress morphine withdrawal symptoms, tramadol dosismg/kg. Convulsions have been reported at therapeutic doses and the risk may be increased at doses exceeding the usual upper daily dose limit, tramadol dosismg/kg.

Patients with a history of epilepsy or those susceptible to seizures should only be treated with tramadol tramadol there are compelling clinical reasons. The risk of convulsions may increase in patients dosismg/kg tramadol and concomitant medication that lowers the seizure threshold see Interactions with other medicaments and other forms of interactions section.

Headache caused by overuse of analgesics MOH - medication-overuse headache should not dosismg/kg treated by increasing the dose. In such tramadol the use of analgesics should be discontinued dosismg/kg consultation with a doctor.

In patients treated with MAO inhibitors in the 14 days prior to the use of the opioid pethidine, tramadol dosismg/kg, tramadol dosismg/kg, life tramadol interactions on the central nervous system, respiratory and cardiovascular function have been observed. The same interactions with Dosismg/kg inhibitors cannot be ruled out during treatment with Tramadol.

Concomitant administration of Tramadol tramadol other centrally depressant medicinal products including alcohol may potentiate the CNS effects see section 4, tramadol dosismg/kg.

Tramadol Dosage

The results of pharmacokinetic dosismg/kg have so far shown that on the concomitant or previous dosismg/kg of cimetidine enzyme inhibitor clinically relevant interactions are unlikely to occur. Simultaneous or previous administration of carbamazepine enzyme inducer may reduce the analgesic effect and shorten the duration of action.

Tramadol can induce convulsions and increase the potential for selective serotonin re-uptake inhibitors, tramadol dosismg/kg, SSRIstramadol dosismg/kg, serotonin-norepinephrine reuptake inhibitors SNRIstricyclic anti-depressants, tramadol dosismg/kg, anti-psychotics and other seizure threshold lowering medicinal products such as bupropion, tramadol dosismg/kg, mirtazapine, tetrahydrocannabinol to cause convulsions, tramadol dosismg/kg.

Concomitant therapeutic use of tramadol and serotonergic drugs, such as selective serotonin reuptake inhibitors SSRIsserotonin-norepinephrine reuptake inhibitors SNRIsMAO inhibitors see section dosismg/kg. Signs of serotonin syndrome may be for example confusion, agitation, tramadol dosismg/kg, fever, sweating, ataxia, hyperreflexia, myoclonus and diarrhoea.

Serotonin syndrome is likely when one of the following is observed: Withdrawal of the serotoninergic medicinal products usually brings about a rapid improvement.

Treatment depends on the nature and severity of the symptoms, tramadol dosismg/kg. Caution should be exercised during concomitant treatment with tramadol and coumarin derivatives e. Other active substances tramadol to inhibit CYP3A4, tramadol as ketoconazole and erythromycin, might inhibit the metabolism of tramadol N-demethylation probably also the metabolism of the active Odemethylated metabolite.

Tramadol clinical importance of such an interaction has not been studied see section 4, tramadol dosismg/kg. In a limited number of studies the pre- or postoperative application of the antiemetic 5-HT3 antagonist ondansetron dosismg/kg the requirement of tramadol in patients with dosismg/kg pain. Teratogenic effects were not observed. Tramadol crosses the placenta.

There is inadequate evidence available on the safety of tramadol in human pregnancy, tramadol dosismg/kg. Therefore dosismg/kg should not be used in pregnant women. Tramadol - tramadol before or during birth - dosismg/kg not affect uterine contractility.

In new-born dosismg/kg it may induce changes in the tramadol rate which are usually not clinically relevant. Tramadol use during pregnancy may lead to neonatal withdrawal symptoms. Breast-feeding During lactation about 0. Tramadol is not recommended during breast-feeding. After a single administration of tramadol it is not usually dosismg/kg to interrupt breast-feeding. Tramadol applies particularly in conjunction with alcohol and other psychotropic substances.

This medicine can impair cognitive function and can affect a patient's ability to drive safely. This class of medicine is in the list of drugs included in regulations under 5a of the Road Traffic Act When prescribing this medicine, patients should be told: These adverse reactions may occur especially on intravenous administration and in patients who are physically stressed.

If tramadol recommended doses are considerably exceeded and other centrally depressant substances are administered concomitantly see section 4. Epileptiform convulsions occurred mainly after administration of high doses of tramadol or after concomitant treatment with medicinal products which can lower the seizure threshold see sections 4, tramadol dosismg/kg.

Psychic adverse reactions may occur following administration of Tramadol which vary individually in intensity and nature depending on personality and duration of treatment, tramadol dosismg/kg. These include changes in mood usually elation, tramadol dosismg/kg, occasionally dysphoria tramadol, changes in activity usually suppression, occasionally increase and tramadol in cognitive and sensorial capacity e. Worsening of asthma has been reported, though a causal relationship has not been established.

In a dosismg/kg isolated cases an increase in liver enzyme values has been reported in a temporal connection with the therapeutic use of tramadol. Renal and urinary disorders: Other symptoms that have very rarely been seen with tramadol discontinuation include: Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important, tramadol dosismg/kg. Healthcare professionals tramadol asked to report any suspected adverse reactions via the Yellow Card Dosismg/kg website: Supportive measures dosismg/kg as maintaining the patency of the airway and maintaining cardiovascular function should be instituted; naloxone should be used to reverse respiratory depression; fits can be controlled with diazepam.

In case of intoxication orally, gastrointestinal decontamination with activated charcoal or by gastric lavage is only recommended within 2 hours after tramadol intake. Gastrointestinal decontamination at a later time point may be useful in case of intoxication with exceptionally large quantities.

Tramadol is minimally eliminated by haemodialysis and haemofiltration. Therefore treatment of acute intoxication with tramadol by haemodialysis or haemofiltration is not recommended, tramadol dosismg/kg. Pharmacological properties Pharmacotherapeutic group: N02A X02 Tramadol is a centrally acting synthetic analgesic dosismg/kg.

It is a non-selective pure agonist at mu, delta and kappa opioid receptors with a higher affinity for the mu receptor, tramadol dosismg/kg. Other mechanisms which may contribute to its analgesic effect are inhibition of neuronal reuptake of dosismg/kg norepinephrine and enhancement of serotonin release. Tramadol opioid activity dosismg/kg from low affinity binding of the parent compound to mu-opioid receptors and higher affinity binding of the active metabolite, O-desmethyl tramadol, tramadol dosismg/kg.

Tramadol to morphine, tramadol dosismg/kg, tramadol does not dosismg/kg respiratory depression when given within the analgesic dosage interval. The gastrointestinal motility is not affected, tramadol dosismg/kg. There is minimal effect on the cardiovascular system, tramadol dosismg/kg.

The contribution to human analgesia of tramadol relative to the active metabolite is unknown. Tramadol has an antitussive effect. Animal studies have revealed a reduced dependence potential compared with morphine and a very slight tolerance tramadol. Paediatric population Effects tramadol enteral and parenteral administration of tramadol have been investigated in clinical trials involving more than paediatric patients ranging in age from neonate to 17 years of age.

The indications dosismg/kg pain treatment studied in those trials included pain after surgery mainly abdominalafter surgical tooth extractions, due to fractures, burns and traumas as well as other painful conditions likely to require analgesic treatment for at least 7 days.

The conducted trials confirmed the efficacy of tramadol. The safety profile of tramadol was similar in adult and paediatric patients older than 1 year see section 4. The difference between absorbed and non-metabolised available tramadol is probably due to the low first-pass effect. Tramadol passes the blood-brain and placental barriers, tramadol dosismg/kg.