Medicine metronidazole 500mg tablets

Name of the medicinal product Metronidazole Tablets mg 2. Qualitative and quantitative composition Each tablet contains metronidazole EP mg Excipients with known effect: It is also active against Trichomonas vaginalis, Entamoeba histolytica, Gardia lamblia, Balantidium coli and Metronidazole tablets. Metronidazole is indicated in medicines and children for the following indications: Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Caution is advised in the elderly, particularly at high doses, although there is limited information available on modification of dosage. Caution is advised in patients with hepatic encephalopathy.

500mg third of the daily dose voltarol tablets 100mg once a day should be considered see section 4. Treatment for 7 days should be satisfactory for most patients but, depending upon clinical and bacteriological assessments, the physician may decide to prolong treatment, eg for eradication of infection from sites which cannot be drained or are liable to endogenous recontamination by anaerobic pathogens from the gut, medicine metronidazole 500mg tablets, oropharynx or genital tract, medicine metronidazole 500mg tablets.

Duration of treatment is usually 7 days. Children under 10 years: A more suitable dosage form should be used for this age group. Prophylaxis against anaerobic infection - chiefly in the context of abdominal especially colorectal and gynaecological surgery.

Metronidazole Tablets 500 mg

Metronidazole and children over 10 years: Where reinfection is likely, sexual partners should be treated concomitantly.

Children 7 to 10 years: Children 3 to 7 years: Children 1 to 3 years: Alternatively, tablets may be expressed by body weight: Children under 7 years: Alternatively, as expressed in mg per kg of body weight: A more suitable medicine form 500mg be used for this age, medicine metronidazole 500mg tablets.

Official guidelines should be consulted before initiating therapy, medicine metronidazole 500mg tablets. Method of Administration 4.

Metronidazole, Oral Tablet

A disulfiram-like reaction with hypotension and flushing has occurred see section 4. High doses of metronidazole may tablet the presence of syphilis. The dosage of metronidazole, therefore, needs no reduction. Such patients, however, retain the metabolites of metronidazole.

The clinical significance of this is not known at medicine. Metronidazole should, therefore, be readministered immediately after haemodialysis. Metronidazole is mainly metabolised by hepatic oxidation.

Substantial impairment of metronidazole clearance may occur in the presence of advanced hepatic insufficiency. Signficant 500mg may occur benazepril 20mg precio tablets with hepatic encephalopathy and the resulting high plasma concentrations of metronidazole may contribute to symptoms of the encephalopathy.

Therefore, medicine metronidazole 500mg tablets, metronidazole should be administered with caution to patients with hepatic metronidazole. The daily dosage should be reduced to one third and may be administered once daily.

In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached.

If the medicine function tests become markedly elevated during treatment, the drug should be discontinued. Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

Lithium retention accompanied by evidence of possible renal damage has been reported in patients treated simultaneously with lithium and metronidazole.

Lithium treatment should be tapered or withdrawn before administering metronidazole. Plasma concentration of lithium, creatinine, and electrolytes should be monitored in patients under treatment with lithium while they receive metronidazole.

Some potentiation of anticoagulant therapy has been reported when metronidazole has been used with the warfarin type oral anticoagulants, medicine metronidazole 500mg tablets. Dosage of the latter may require reducing. Prothrombin times should be monitored. No interactions have been 500mg with anticoagulants of the heparin metronidazole.

What Is Metronidazole Used To Treat STD?

However, anticoagulant activity should be routinely monitored with these products. Patients should be advised not to take alcohol during metronidazole therapy and for at least 48 hours after 500mg of the possibility of a disulfiram-like reaction. Psychotic reactions have been reported. Patients receiving ciclosporin are at risk of elevated ciclosporin serum levels. Serum ciclosporin and serum creatinine should be closely monitored when coadministration is necessary.

Patients receiving phenobarbital metabolise metronidazole at a much greater rate than normally, reducing the half-life to approximately 3 hours. Metronidazole inhibits metabolism of phenytoin increases plasma-phenytoin concentration. Primidone accelerates the metabolism of Metronidazole causing reduced plasma concentrations. Metronidazole inhibits metabolism of fluorouracil.

Therefore, increased toxicity of fluorouracil can result. Cimetidine inhibits the metabolism of metronidazole medicines plasma-metronidazole concentration, medicine metronidazole 500mg tablets. Aspartate amino transferase assays may give spuriously low metronidazole in patients taking metronidazole, depending on the method used.

Pregnancy Metronidazole is contraindicated in the first trimester see section 4. For all tablet indications Metronidazole should only be used if the benefits outweight the risks or no other alternative is available especially in the first trimester.

Breast-feeding It is advisable to stop breast feeding until 12 — 24 hours after Metronidazole therapy has been discontinued see section 4. The frequency of adverse events listed below is defined using the following convention: