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Active liver disease or unexplained persistent elevations of serum transaminases.

Is atorvastatin the same as lipitor

Hypersensitivity to any component of this medication. Pregnancy and Lactation Atherosclerosis is a chronic process and discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. Cholesterol and hyzaar price generic products of cholesterol biosynthesis are essential components for fetal development including synthesis of steroids and cell membranes.

Since HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, they may cause fetal harm when administered to pregnant women. If the patient becomes pregnant while taking this drug, therapy should be discontinued and the patient apprised of the potential hazard to the fetus.

The incidence of 10mg abnormalities was 0. One patient in clinical trials developed jaundice. Increases in liver function tests LFT in other thuoc were not associated with jaundice or other clinical signs or symptoms.

Upon dose reduction, drug interruption, or discontinuation, transaminase levels returned to or near pretreatment levels without sequelae. Eighteen of 30 patients with persistent LFT elevations continued treatment with a reduced dose of atorvastatin. It is lipitor that liver function tests be performed prior to and at 12 weeks following both the initiation of therapy and any elevation of dose, and periodically e.

Liver enzyme changes generally occur in the first 3 months of treatment with atorvastatin. Patients who develop increased transaminase levels should be monitored until the abnormalities resolve. Skeletal Muscle Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with atorvastatin and with other drugs in this class. Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.

Atorvastatin therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected. The risk of myopathy during treatment with drugs in this class is increased with concurrent administration of cyclosporine, fibric acid derivatives, erythromycin, clarithromycin, combination of ritonavir plus saquinavir or lopinavir plus ritonavir, thuoc lipitor 10mg, niacin, or azole 10mg. Physicians considering combined therapy with atorvastatin and fibric acid derivatives, erythromycin, clarithromycin, a combination of ritonavir plus saquinavir or lopinavir plus ritonavir, immunosuppressive drugs, azole antifungals, or lipid-modifying doses of niacin should carefully weigh the potential benefits and risks and should carefully monitor patients for any lipitor or symptoms of muscle pain, tenderness, thuoc lipitor 10mg, or weakness, particularly during the initial months of therapy and during any periods of upward dosage titration of either drug.

Periodic creatine phosphokinase CPK determinations may be considered in such situations, but there is no assurance that such monitoring will prevent the occurrence of severe myopathy. Atorvastatin therapy should be temporarily withheld or discontinued in any patient with an acute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to thuoc e.

Information for Patients Patients 10mg be advised to report promptly unexplained muscle pain, thuoc lipitor 10mg, tenderness, or weakness, particularly if accompanied by malaise or fever. Drug Interactions The risk of myopathy during treatment with HMG-CoA reductase 10mg is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of niacin or cytochrome P 3A4 inhibitors e. Concomitant administration of atorvastatin with inhibitors of cytochrome P 3A4 can lead to increases in plasma concentrations of atorvastatin, thuoc lipitor 10mg.

The extent of interaction 10mg potentiation of effects depends on the variability of effect on cytochrome P 3A4.

Clarithromycin Concomitant administration of atorvastatin 80 lipitor with clarithromycin mg twice daily resulted in a 4. Combination of Protease Inhibitors Concomitant administration of atorvastatin 40 mg vigora 5x price ritonavir plus saquinavir mg twice daily resulted in a 3-fold increase in atorvastatin AUC.

Itraconazole Concomitant administration of atorvastatin 20 to 40 mg and itraconazole mg was associated with a 2. Diltiazem hydrochloride Co-administration of atorvastatin 40 mg with diltiazem mg was associated with higher plasma concentrations of atorvastatin. Cimetidine Atorvastatin plasma concentrations and LDL-C reduction were not altered by co-administration of cimetidine. Concomitant administration of atorvastatin 10 mg and thuoc 5. Inducers of cytochrome P 3A4 Concomitant administration of atorvastatin with inducers of cytochrome P 3A4 eg efavirenz, rifampin can lead to variable reductions in plasma concentrations of atorvastatin.

Due to the dual interaction mechanism of rifampin, simultaneous co-administration of atorvastatin with rifampin is recommended, as delayed administration of atorvastatin after administration of rifampin has been associated with a lipitor reduction in atorvastatin plasma concentrations.

However, LDL-C reduction was not altered. Antipyrine Because atorvastatin does not affect the pharmacokinetics of antipyrine, thuoc lipitor 10mg, interactions with other drugs metabolized via the same cytochrome isozymes are 10mg expected. However, thuoc lipitor 10mg, LDL-C thuoc was greater when atorvastatin and colestipol were thuoc than when either drug was given alone.

Patients taking digoxin should be monitored appropriately. These increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin. Warfarin Atorvastatin had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment. Clinical studies have shown that atorvastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, thuoc lipitor 10mg.

The effects of HMG-CoA reductase inhibitors on male fertility have not been studied in adequate 10mg of patients. The effects, if any, on the pituitary-gonadal axis in lipitor women are unknown. Lipitor should be exercised if an HMG-CoA reductase inhibitor lipitor administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones, thuoc lipitor 10mg, such as thuoc, spironolactone, and cimetidine.

CNS vascular lesions, thuoc lipitor 10mg, characterized by perivascular hemorrhages, edema, and mononuclear cell infiltration of perivascular spaces, have been observed in dogs treated with other members of this class. A chemically similar drug in this class produced optic nerve degeneration Wallerian thuoc of retinogeniculate fibers in clinically normal dogs in a dose-dependent fashion at a dose that produced plasma drug levels about 30 times higher than buy cialis online no prescription lipitor drug level in humans taking the thuoc recommended dose.

This dose represents lipitor plasma AUC 0—24 value of approximately 16 times the mean human plasma drug exposure after 10mg 80 mg oral dose, thuoc lipitor 10mg. These findings thuoc at plasma AUC 10mg values of approximately 6 times the mean human plasma drug exposure after an 80 mg oral dose.

In vitro, atorvastatin was not mutagenic or clastogenic in the following tests with and without metabolic activation: Atorvastatin was negative in the in buy tramadol direct mouse micronucleus test. Atorvastatin crosses the rat placenta and reaches a level in fetal liver equivalent to that of maternal plasma, thuoc lipitor 10mg.

Rare reports of congenital anomalies have been received following intrauterine exposure to HMG-CoA reductase inhibitors. There has been one report of severe congenital bony deformity, tracheo-esophageal fistula, thuoc lipitor 10mg, and anal thuoc VATER association in a baby born to a woman who took lovastatin with dextroamphetamine sulfate during the first trimester of 10mg. LIPITOR should be administered to women lipitor child-bearing potential only when such patients are highly unlikely to conceive and have been informed of the potential hazards.

Proscar pharmacy online the woman becomes pregnant while taking LIPITOR, it should be discontinued and the patient advised again as to the potential hazards to the fetus. Pediatric Use Safety and effectiveness in patients 10—17 years of age with heterozygous familial hypercholesterolemia have thuoc evaluated in a controlled clinical trial of 6 months duration in adolescent boys and postmenarchal girls.

Patients treated with LIPITOR had an adverse experience profile generally similar to that of patients treated with placebo, the most common adverse experiences observed in both groups, regardless of causality assessment, were infections. Doses greater than 20 mg have not been studied in this patient population.

LIPITOR has not been studied in controlled clinical trials involving pre-pubertal patients or patients younger than 10 years of lipitor. In this week open-label trial 1, patients initiated therapy with atorvastatin 10 mg. The mean change in LDL-C 10mg baseline after 6 weeks of treatment with atorvastatin 10 mg was — The rates of discontinuation due to adverse events were similar between the two age groups.

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There were no differences in 10mg relevant laboratory abnormalities between the age groups. Subjects with hemorrhagic stroke on study entry appeared to be at thuoc risk lipitor hemorrhagic stroke, thuoc lipitor 10mg.

Thuoc reactions have usually been mild and transient. The most frequent adverse events thought to be related to atorvastatin were constipation, 10mg, dyspepsia, lipitor abdominal pain.