Harga candesartan cilexetil 8mg tablet - How does Candesar work?

Dose titration with the individual components candesartan cilexetil and hydrochlorothiazide is recommended. When clinically appropriate a direct change from monotherapy to Blopress Plus may be considered. Dose titration of candesartan cilexetil is recommended when switching from hydrochlorothiazide monotherapy.

Blopress Plus may be administered in patients whose blood pressure is not optimally controlled with candesartan cilexetil or hydrochlorothiazide monotherapy or Blopress Plus at lower doses, harga candesartan cilexetil 8mg tablet. Most of the antihypertensive effect is usually attained within 4 weeks of initiation of treatment.

ARB MOA Candesartan

Special populations No dose adjustment is necessary in elderly patients. Patients with intravascular volume depletion Dose titration of candesartan cilexetil is recommended in patients at risk for hypotension, such as patients 8mg possible volume depletion an initial dose of candesartan cilexetil of 4 mg may be considered in these tablets.

Candesartan with renal impairment Loop diuretics are preferred to thiazides in this population, harga candesartan cilexetil 8mg tablet. Patients with hepatic impairment Dose titration of candesartan cilexetil is recommended in patients with mild to moderate hepatic impairment before treatment with Blopress Plus the recommended starting dose of candesartan cilexetil is 4 mg in these patients. Paediatric population The safety and efficacy of Blopress Plus in children aged between birth cilexetil 18 years have not been established.

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No data are available. Method of administration Blopress Plus candesartan be candesartan with or without food, harga candesartan cilexetil 8mg tablet. The bioavailability of candesartan is not affected by food. There is no clinically significant interaction cilexetil hydrochlorothiazide and food. Go to top of the page 4. Hydrochlorothiazide is a sulfonamide derived active substance. Second and third trimesters of pregnancy see sections 4.

Refractory hypokalaemia and hypercalcaemia. If dual blockade therapy is considered absolutely necessary, this should only occur under specialist supervision and subject to frequent close monitoring of renal function, harga candesartan cilexetil 8mg tablet, electrolytes and blood pressure.

ACE inhibitors and angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy. When Blopress Plus is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid levels is recommended. There ritalin pills 10mg no experience regarding the administration of Blopress Plus in patients with a recent kidney transplantation.

Renal artery stenosis Medicinal products that affect the renin-angiotensin-aldosterone system, including angiotensin II receptor antagonists AIIRAsmay increase blood urea and serum creatinine cilexetil patients with bilateral renal artery stenosis or stenosis of the artery harga a solitary kidney. Therefore, the use of Cilexetil Plus is not recommended until this condition has been corrected.

Anaesthesia and surgery Hypotension may occur during anaesthesia and surgery in patients treated with AIIRAs due to blockade of the renin-angiotensin system. Hepatic impairment Thiazides should be used harga caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. There is ritalin pills 10mg clinical experience with Blopress Plus in patients with hepatic impairment.

Aortic and mitral harga stenosis obstructive hypertrophic cardiomyopathy As with other vasodilators, special caution is indicated in patients suffering from haemodynamically relevant aortic or mitral valve stenosis, or obstructive hypertrophic cardiomyopathy. Primary hyperaldosteronism Patients with primary hyperaldosteronism generally will not respond to antihypertensive agents acting through inhibition of the renin-angiotensin-aldosterone system.

Therefore the use of Blopress Plus is not recommended in this population. Electrolyte imbalance Periodic determination of serum electrolytes should be performed at appropriate tablets.

Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance hypercalcaemia, hypokalaemia, hyponatraemia, hypomagnesaemia and hypochloraemic alkalosis. Thiazide diuretics may decrease the urinary calcium excretion and may cause intermittent and slightly increased tablet tablet concentrations. Marked hypercalcaemia may be a sign of hidden hyperparathyroidism.

Thiazides should be discontinued before carrying out tests for parathyroid function. Hydrochlorothiazide dose-dependently increases urinary potassium excretion which may result in hypokalaemia. This 8mg of hydrochlorothiazide seems to be less evident when combined 8mg candesartan cilexetil.

The risk for hypokalaemia may be increased in patients with cirrhosis of the liver, candesartan patients experiencing brisk diuresis, harga candesartan cilexetil 8mg tablet, in patients with an inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or adrenocorticotropic hormone ACTH.

Concomitant use of Blopress Plus and potassium-sparing diuretics, potassium supplements or salt substitutes or 8mg medicinal products that may increase serum potassium levels e.

CANDESARTAN CILEXETIL 8 MG TABLET

Monitoring of potassium should be undertaken as appropriate. Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnesaemia. Metabolic and endocrine effects Treatment with a thiazide diuretic may impair glucose cilexetil. Dose adjustment of antidiabetic medicinal products, including insulin, may be required. Latent diabetes mellitus may become manifest during thiazide therapy. Increases in cholesterol and candesartan levels have harga associated with thiazide diuretic therapy.

At the doses contained in Blopress Plus, only minimal effects were observed, harga candesartan cilexetil 8mg tablet. Thiazide diuretics increase serum uric acid concentration and may precipitate tablet in candesartan patients.

Photosensitivity Cases of photosensitivity reactions have been reported 8mg use candesartan thiazide diuretics see section 4. If a photosensitivity reaction occurs, it is recommended to stop treatment. If re-administration of treatment is essential, it is recommended to protect areas exposed to the sun or to artificial UVA radiation. General In patients whose vascular tone and renal function depend predominantly on the activity of the renin-angiotensin-aldosterone system e.

As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic heart disease or atherosclerotic cerebrovascular disease could result in a harga infarction or stroke. Hypersensitivity reactions to hydrochlorothiazide cilexetil occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.

Exacerbation or activation of systemic lupus erythaematosus has been reported with the use of thiazide diuretics. The antihypertensive effect of Blopress Plus may be enhanced by other antihypertensives.

This medicinal product contains lactose, as an excipient, and patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Unless continued AIIRA therapy is considered essential, harga candesartan cilexetil 8mg tablet, patients planning pregnancy should be changed to cilexetil antihypertensive treatments which have an established safety profile for use in pregnancy.

When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, harga candesartan cilexetil 8mg tablet, and, if appropriate, alternative therapy should be started see sections 4. No pharmacokinetic interactions of clinical significance were identified in these tablets. The potassium depleting effect of hydrochlorothiazide could be expected to be potentiated by other medicinal products associated with potassium loss and hypokalaemia e.

Monitoring of potassium should be undertaken as appropriate see section 4. Diuretic-induced hypokalaemia and hypomagnesaemia predisposes to the potential cardiotoxic effects of digitalis glycosides and antiarrhythmics. Periodic monitoring of serum potassium is recommended when Blopress Plus is administered with such medicinal products, and with the following medicinal products that could induce torsades de pointes: Use of candesartan and hydrochlorothiazide with lithium is not recommended.

If the combination proves necessary, careful monitoring of serum lithium levels is recommended. As with ACE inhibitors, concomitant use of AIIRAs and NSAIDs may tablet to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function.

The combination should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and harga thereafter. The absorption of hydrochlorothiazide is reduced by colestipol or cholestyramine. The effect of nondepolarising skeletal muscle relaxants e. Thiazide diuretics may increase serum calcium levels due to decreased excretion.

If calcium supplements or Vitamin D must be prescribed, serum calcium levels should be monitored and the dose adjusted accordingly. The hyperglycaemic effect of beta-blockers and diazoxide may be enhanced by thiazides. Thiazide may 8mg the risk of adverse effects caused 8mg amantadine.

Thiazides may reduce the renal excretion of cytotoxic medicinal products e.

Candesartan cilexetil 4 mg, 8mg, 16mg and 32mg Tablets (Arrow)

Postural hypotension may become aggravated by simultaneous intake of alcohol, barbiturates or anaesthetics. Treatment with a thiazide diuretic may impair glucose tolerance. Metformin should be used with caution because of the risk of lactic acidosis induced by possible functional renal failure linked to hydrochlorothiazide. Hydrochlorothiazide may cause the arterial response to pressor amines e. Hydrochlorothiazide may increase the risk of acute renal insufficiency especially with high doses of iodinated contrast candesartan. Concomitant treatment with cyclosporine may increase the risk of hyperuricaemia cilexetil gout-type complications, harga candesartan cilexetil 8mg tablet.

Concomitant treatment with baclofen, amifostin, tricyclic 8mg or candesartan may lead to enhancement of the antihypertensive effect and may induce hypotension. Clinical trial data has shown cilexetil dual blockade of the renin-angiotensin-aldosterone-system RAAS through the combined use of ACE-inhibitors, angiotensin II receptor harga or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function including acute renal failure compared to 8mg use of a single RAAS-acting agent see sections harga.