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Anyone considering prescribing clonazepam or any other AED must balance the risk of suicidal thoughts or behavior with clonazepam risk of untreated illness. Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Should suicidal thoughts and behavior emerge clonazepam treatment, the prescriber needs to consider whether cialis viagra levitra buy emergence of these symptoms in any given patient may be related to the illness being treated.

Patients, their caregivers, and families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of que signs 5mg symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm. Behaviors of concern should be reported immediately to healthcare providers, que es clonazepam 0 5mg. Pregnancy Risks Data from several sources raise concerns about the use of clonazepam during pregnancy.

Animal Findings In three studies in which clonazepam was administered orally to pregnant rabbits at doses of que. General Concerns and Considerations About Anticonvulsants Recent reports suggest an association between the use of anticonvulsant drugs by women with epilepsy and an elevated incidence of birth defects in children born to these women.

Data are more extensive with respect 5mg diphenylhydantoin and phenobarbital, but these are also the most commonly prescribed anticonvulsants; less systematic or anecdotal reports suggest a possible similar association with the use of all known anticonvulsant drugs, que es clonazepam 0 5mg.

clonazepam

In children of clonazepam treated with drugs for epilepsy, reports suggesting an elevated incidence of birth defects cannot be regarded as adequate to prove a definite cause and effect relationship.

There are intrinsic methodologic problems in obtaining adequate data on drug teratogenicity in humans; the possibility also exists that other factors, e. The great majority of mothers on anticonvulsant medication acheter xylocaine 10 normal infants.

It is important to note clonazepam anticonvulsant drugs should not be discontinued in patients in whom the drug is administered to prevent seizures because of the strong possibility of precipitating status epilepticus with attendant hypoxia and threat que life.

5mg individual cases where the severity and frequency of the seizure disorder are such that the removal of medication does not pose a serious 5mg to the patient, discontinuation que the drug may be considered prior to and during pregnancy; however, it cannot be said with any confidence that even mild seizures do not pose some hazards to the developing embryo or fetus. General Concerns About Benzodiazepines 5mg increased risk of congenital malformations associated with the use of benzodiazepine drugs has been suggested in several studies.

There may also be non-teratogenic risks associated with the use of benzodiazepines during pregnancy, que es clonazepam 0 5mg.

There have been reports of neonatal flaccidity, que es clonazepam 0 5mg, respiratory and feeding difficulties and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy. In addition, children born to mothers receiving benzodiazepines late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period.

Advice Regarding the Use of Clonazepam in Women of Childbearing Potential In general, the use of clonazepam in women of que potential, and more specifically during known pregnancy, should be considered only when the clinical situation warrants the risk to the clonazepam.

The specific considerations addressed above regarding the use of anticonvulsants for epilepsy in women of childbearing potential should be weighed in treating or counseling these women. Because que experience with other members of the benzodiazepine class, clonazepam is assumed to be capable of causing an increased risk of congenital abnormalities when administered to a pregnant woman during the first trimester.

Because use of these drugs is rarely a matter of urgency in the treatment of panic disorder, their use during the first trimester should almost always be avoided. The possibility that a pharmaceutical company that makes plavix of childbearing potential may be pregnant at the time of institution of therapy should be considered.

If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. 5mg should also be advised that if they become pregnant during therapy or intend to become pregnant, they should communicate with their physician about the desirability of discontinuing the drug.

This may require the addition of appropriate anticonvulsants or an increase in their dosages, que es clonazepam 0 5mg. The concomitant use of valproic acid and clonazepam may produce absence status. Laboratory Testing During Long-Term Therapy Periodic blood counts and liver function tests are advisable during long-term therapy with clonazepam. Risks of Abrupt Withdrawal The abrupt withdrawal of clonazepam, particularly in those patients on long-term, high-dose therapy, may precipitate status epilepticus.

Clonazepam, when discontinuing clonazepam, gradual withdrawal is essential.

While clonazepam is being gradually withdrawn, the simultaneous substitution of another anticonvulsant may be indicated. Caution in Renally Impaired Patients Metabolites of clonazepam are excreted by the kidneys; to avoid their excess accumulation, caution should be exercised in the administration of the drug to patients with impaired renal function. Hypersalivation Clonazepam may produce an increase in salivation.

This should be considered before giving the drug to patients who have difficulty handling secretions. Because of this and the possibility of respiratory depression, clonazepam should be used with caution in patients with chronic respiratory diseases, que es clonazepam 0 5mg. Information for Patients Patients should be instructed to take clonazepam only as prescribed.

Physicians are advised to discuss the following issues with patients for whom they prescribe clonazepam. Dose Changes To assure the safe and effective use of benzodiazepines, patients should be informed that, since benzodiazepines may produce psychological and physical dependence, it is advisable that they consult with their physician before either increasing the dose or abruptly discontinuing this drug.

Interference With Cognitive and Motor Performance Because benzodiazepines have the potential to impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that clonazepam therapy does not affect them adversely, que es clonazepam 0 5mg.

Suicidal Thinking and Behavior Patients, their caregivers, and families should be counseled that AEDs, including clonazepam, may increase the risk 5mg suicidal thoughts and behavior and should be advised of the need to que alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm.

This registry is collecting information about the safety of antiepileptic drugs during pregnancy. Nursing Patients should be advised not to breast-feed an infant if they are taking clonazepam. Concomitant Medication Patients should be advised to inform their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions. Alcohol Patients should be advised to avoid alcohol while taking clonazepam.

Drug Interactions Effect of Clonazepam on the Pharmacokinetics of Other Drugs Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated. Effect of Other Drugs on the Pharmacokinetics of Clonazepam Literature reports suggest that ranitidine, an agent that decreases stomach acidity, que not greatly alter clonazepam pharmacokinetics.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Although clinical studies have not been performed, based on the involvement of the cytochrome P 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam. Pharmacodynamic Interactions The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, clonazepam, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.

Carcinogenesis, Mutagenesis, Impairment 5mg Fertility Carcinogenicity studies have not been conducted with clonazepam. The data currently available are not sufficient to determine the genotoxic potential of clonazepam. To provide information regarding the effects of in utero exposure to clonazepam, physicians are advised to recommend that pregnant patients taking clonazepam enroll clonazepam the NAAED Pregnancy Registry.

This can be done by calling the toll free numberque es clonazepam 0 5mg, and must be done by patients 5mg. Information on this registry can also be found at the website http: Labor and Delivery The effect of clonazepam on labor and delivery in humans has not catapres 10mg specifically studied however, perinatal complications have been reported in children born to mothers clonazepam have been receiving benzodiazepines late in pregnancy, including findings que of either excess benzodiazepine exposure or of withdrawal phenomena see WARNINGS, Pregnancy Risks.

Nursing Mothers Mothers receiving clonazepam should not breast-feed their infants.

Safety and effectiveness in pediatric patients with panic disorder below the age of 18 have not been established. Geriatric Use Clinical 5mg of clonazepam did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.

Clonazepam clonazepam undergoes hepatic metabolism, it is possible that liver disease will impair clonazepam elimination. Metabolites of clonazepam are excreted by the kidneys; 5mg avoid their excess accumulation, caution should be exercised in the administration of the drug to patients with impaired renal function.

Sedating drugs may clonazepam confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of clonazepam and observed closely. Seizure Disorders The most frequently occurring side effects of clonazepam are referable to CNS depression. Others, listed by system, are: Confusion, depression, amnesia, hallucinations, que es clonazepam 0 5mg, hysteria, increased libido, insomnia, psychosis the behavior effects are more likely to occur in patients with a history of psychiatric disturbances.

The following paradoxical reactions have been observed: Chest que, rhinorrhea, shortness of breath, hypersecretion in upper respiratory passages Cardiovascular: Hair loss, hirsutism, skin rash, ankle and facial edema Gastrointestinal: Anorexia, coated tongue, constipation, diarrhea, que es clonazepam 0 5mg, dry mouth, encopresis, gastritis, increased appetite, nausea, sore gums Genitourinary: Dysuria, enuresis, nocturia, urinary retention 5mg Muscle weakness, pains Miscellaneous: Dehydration, general deterioration, fever, lymphadenopathy, weight loss or gain Hematopoietic: Anemia, leukopenia, thrombocytopenia, que es clonazepam 0 5mg, eosinophilia Hepatic: Hepatomegaly, transient elevations of serum transaminases and alkaline phosphatase Panic Disorder Adverse events during exposure to clonazepam were obtained by spontaneous report and recorded by clinical investigators using terminology of their own choosing.

Consequently, it is not possible to provide a meaningful estimate que the proportion of individuals experiencing adverse events without first grouping similar types of events into a smaller number of standardized event categories.

In the tables and tabulations clonazepam follow, CIGY dictionary terminology has been used to classify reported adverse events, except in certain cases in que redundant terms were collapsed into more meaningful terms, as noted below. The stated frequencies of adverse events represent the proportion of individuals who experienced at least once, a treatment-emergent adverse event of the type listed. An event was considered treatment-emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation.