Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent. Beneficial effects of resveratrol on atherosclerosis. J Med Food ;11 4: Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. Biological activity of acetylated phenolic compounds. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment.
Journal of Urology ; Fulda, S. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol.
The potential of resveratrol against human gliomas. Anticancer Drugs ;21 2: Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol.
Contact Dermatitis ;48 3: Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: Mechanism-based in vitro screening of potential cancer chemopreventive agents. Prostaglandin endoperoxide synthase types 1 and 2: Ontogenetic expression and effects of inhibition on the basal and estrogen stimulated fetal ovine hypothalamus-pituitary adrenal axis.
An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys.
Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans.
Journal of Hypertension ;28 Guarente, L. Sirtuins in aging and disease. Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cells. Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U cell line. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.
A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. Antioxidant activity of resveratrol closely correlated with its monoamine oxidase-A inhibitory activity. The effect of resveratrol on longevity across species: Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells.
Food Chem ;53 3: Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. Inhibition of gastric cancer cell proliferation by resveratrol: Liver Physiol ; 5: Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers.
Planta Med ;71 5: Phase I randomized, double-blind pilot study of micronized resveratrol SRT in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Res Phila ;4 9: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines.
Anticancer Res ;20 1A: Genistein, resveratrol, and 5-aminoimidazolecarboxamidebeta-D-ribofuranoside induce cytochrome P 4F2 expression through an AMP-activated protein kinase-dependent pathway. Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability.
Resveratrol, a natural chemopreventive agent against degenerative diseases. Resveratrol and quercetin inhibit angiogenesis in vitro. Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice.
Fukuoka Igaku Zasshi ;96 5: Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: Protective effect of resveratrol in severe acute pancreatitis-induced brain injury. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines.
Investigation into the rapid effects of 17 beta-estradiol and neuroactive steroids upon beta-amyloid -induced activation of phosphoinositide-specific phospholipase C in human platelets. Fungicidal effect of resveratrol on human infectious fungi. Arch Pharm Res ;28 5: Substrate-specific activation of sirtuins by resveratrol.
Inhibition of low-density lipoprotein oxidation by Nagano purple grape Vitis viniferaxVitis labrusca. Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines. Circulation ; Kaneko, H. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD.
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Naturally occurring phytochemicals for the prevention of Alzheimer's disease.
Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food.
A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Rational design of potent human transthyretin amyloid disease inhibitors. Estrogenic activity in white and red wine extracts.
Food Chem ;51 7: Journal of Urology ; 4 Knight, C. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Resveratrol impairs the release of steroid-resistant inflammatory cytokines from human airway smooth muscle cells in chronic obstructive pulmonary disease.
Resveratrol and novel potent activators of SIRT1: Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Role of resveratrol in prevention and therapy of cancer: Pro-oxidant activity of low doses of resveratrol inhibits hydrogen peroxide-induced apoptosis. Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells.
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Food Res ;53 Suppl 1: Assessment of resveratrol bioavailability in the perfused small intestine of the rat.
The protective effects of the antioxidant alpha-lipoic acid against ethanol-mediated toxicity in fetal rhombencephalic neurons. Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism. Regioselective and stereospecific glucuronidation of trans- and cis-resveratrol in human.
Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB human breast cancer cells. Cancer chemoprevention by resveratrol: Increased radiation sensitivity of an eosinophilic cell line following treatment with epigallocatechin-gallate, resveratrol and curcuma. Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene NAG-1 by increasing the expression of p Free radicals and grape seed proanthocyanidin extract: An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: Suppression of 7,dimethylbenz a anthracene-induced mammary carcinogenesis in rats by resveratrol: Cancer Res ;62 Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.
Ageing Dev ; Comparative neuroprotective properties of stilbene and catechin analogs: Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols. Alzheimer Res ;8 5: Therapeutic potential of resveratrol: Nat Rev Drug Discov.
Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells. Resveratrol inhibits TNF alpha-induced endothelial cell activation. Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma Ishikawa cells.
Biological effects of resveratrol. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Melanoma Res ;21 3: Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women. Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage.
J ; Pt 1: Modulation of steroid activity in chronic inflammation: Food Res ;52 9: Effects of resveratrol on lymphocyte proliferation and cytokine release. Does resveratrol induce pharmacological preconditioning? Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.
Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Flavonoid effects relevant to cancer. Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle. Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: Crystal structure of quinone reductase 2 in complex with resveratrol. Resveratrol protects against a model of vacuous chewing movements induced by reserpine in mice.
Nonalcoholic compounds of wine: Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants. J Asian Nat Prod. Cancer Res ;10 Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: Effect of resveratrol on some activities of isolated and in whole blood human neutrophils.
Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P 3A4. Life Sci ;67 Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P 1B1. Phytochemical composition of nuts. Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.
Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Res Phila ;3 9: Approved The serum concentration of Estrone sulfate can be decreased when it is combined with Thiorphan. Approved The serum concentration of Ethinyl Estradiol can be decreased when it is combined with Thiorphan. Approved The serum concentration of Etravirine can be decreased when it is combined with Thiorphan.
Approved The serum concentration of Thiorphan can be decreased when it is combined with Garlic. Approved The serum concentration of Hexestrol can be decreased when it is combined with Thiorphan. Withdrawn The serum concentration of Imipramine can be increased when it is combined with Thiorphan.
Approved The serum concentration of Iprindole can be increased when it is combined with Thiorphan. Experimental The serum concentration of Lofepramine can be increased when it is combined with Thiorphan. Experimental The serum concentration of Lovastatin can be increased when it is combined with Thiorphan. Approved, Investigational The serum concentration of Mestranol can be decreased when it is combined with Thiorphan. Approved The serum concentration of Methallenestril can be decreased when it is combined with Thiorphan.
Experimental The serum concentration of Methylergometrine can be increased when it is combined with Thiorphan. Approved The serum concentration of Midazolam can be increased when it is combined with Thiorphan. Approved, Illicit The serum concentration of Mirtazapine can be increased when it is combined with Thiorphan. Approved The serum concentration of Nefazodone can be increased when it is combined with Thiorphan.
Approved, Withdrawn The serum concentration of Nortriptyline can be increased when it is combined with Thiorphan. Approved The serum concentration of Opipramol can be increased when it is combined with Thiorphan. Investigational The risk or severity of adverse effects can be increased when Thiorphan is combined with Pethidine.
Approved The serum concentration of Pimozide can be increased when it is combined with Thiorphan. Approved The serum concentration of Protriptyline can be increased when it is combined with Thiorphan.
Approved The serum concentration of Riociguat can be increased when it is combined with Thiorphan. Approved The serum concentration of Rosuvastatin can be increased when it is combined with Thiorphan. Approved The serum concentration of Sildenafil can be increased when it is combined with Thiorphan.
Approved, Investigational The serum concentration of Simeprevir can be increased when it is combined with Thiorphan. Approved The serum concentration of Simvastatin can be increased when it is combined with Thiorphan. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature.
The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
Different short- and long-term effects of resveratrol on nuclear factor-kappaB phosphorylation and nuclear appearance in human endothelial cells. Effect of sicherheitsdatenblatt on the expression of autocrine growth modulators in human breast cancer cells. Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production. Cancer Res ;70 Fungicidal effect of resveratrol on human infectious fungi. Immunohistochemistry Estradiol treatment prevents injury induced enhancement in spinal cord dynorphin expression. Approved, Investigational The serum concentration of Cabergoline can be increased alpha it is combined estradiol Thiorphan, alpha estradiol sicherheitsdatenblatt. Approved The metabolism of Rotigotine can be decreased when combined with Tenofovir disoproxil. Contact Dermatitis ;48 3: Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes.
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