Some of these reactions with azithromycin have resulted in recurrent symptoms and required a longer period of observation and treatment. Hepatotoxicity Since the liver is the principal route of elimination for azithromycin, the use of azithromycin should be undertaken with caution in patients with significant hepatic disease. Cases of fulminant hepatitis potentially leading to life-threatening liver failure have been reported with azithromycin see section 4.
Some patients may have had pre-existing hepatic disease or may have been taking other hepatotoxic medicinal products. Azithromycin administration should be stopped if liver dysfunction has emerged. Ergot derivatives In patients receiving ergot derivatives, ergotism has been precipitated by co-administration of some macrolide antibiotics. There are no data concerning the possibility of an interaction between ergot and azithromycin.
However, because of the theoretical possibility of ergotism, azithromycin and ergot derivatives should not be co-administrated. Prolongation of the QT interval Prolonged cardiac repolarisation and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been seen in treatment with other macrolides. A similar effect with azithromycin cannot be completely ruled out in patients at increased risk for prolonged cardiac repolarisation see section 4.
Superinfection As with any antibiotic preparation, observation for signs of superinfection with non-susceptible organisms including fungi is recommended. Clostridium difficile associated diarrhoea Clostridium difficile associated diarrhoea CDAD has been reported with the use of nearly all antibacterial agents, including azithromycin, and may range in severity from mild diarrhoea to fatal colitis.
Hypertoxin producing strains of C. Therefore, CDAD must be considered in patients who present with diarrhoea during or subsequent to the administration of any antibiotics. Careful medical history is necessary since CDAD has been reported to occur over 2 months after the administration of antibacterial agents. Discontinuation of therapy with azithromycin and the administration of specific treatment for C.
Azithromycin is in general effective against streptococcus in the oropharynx, but no data are available that demonstrate the efficacy of azithromycin in preventing acute rheumatic fever. Myasthenia gravis Exacerbations of the symptoms of myasthenia gravis and new onset of myasthenia syndrome have been reported in patients receiving azithromycin therapy see section 4.
Diabetes Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Throw away any unused liquid after 14 days. Dosage Information in more detail What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What should I avoid while taking ciprofloxacin? Do not take ciprofloxacin with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking ciprofloxacin.
They could make the medication less effective. Avoid taking the following medicines within 6 hours before or 2 hours after you take this medicine. These other medicines can make ciprofloxacin much less effective when taken at the same time: Avoid caffeine while you are taking this medicine, as ciprofloxacin can make the effects of caffeine stronger.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. A similar effect with azithromycin cannot be completely ruled out in patients at increased risk for prolonged cardiac repolarisation see section 4. Superinfection As with any antibiotic preparation, observation for signs of superinfection with non-susceptible organisms including fungi is recommended.
Clostridium difficile associated diarrhoea Clostridium difficile associated diarrhoea CDAD has been reported with the use of nearly all antibacterial agents, including azithromycin, and may range in severity from mild diarrhoea to fatal colitis. Hypertoxin producing strains of C. Therefore, CDAD must be considered in patients who present with diarrhoea during or subsequent to the administration of any antibiotics.
Careful medical history is necessary since CDAD has been reported to occur over 2 months after the administration of antibacterial agents. Discontinuation of therapy with azithromycin and the administration of specific treatment for C. Azithromycin is in general effective against streptococcus in the oropharynx, but no data are available that demonstrate the efficacy of azithromycin in preventing acute rheumatic fever.
Myasthenia gravis Exacerbations of the symptoms of myasthenia gravis and new onset of myasthenia syndrome have been reported in patients receiving azithromycin therapy see section 4. Diabetes Caution in diabetic patients: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
In patients receiving both azithromycin and antacids, the drugs should not be taken simultaneously. In healthy volunteers, co-administration of a 5-day regimen of azithromycin with 20 mg cetirizine at steady-state resulted in no pharmacokinetic interaction and no significant changes in the QT interval.
Some of the macrolide antibiotics have been reported to impair the microbial metabolism of digoxin in the gut in some patients. In patients receiving concomitant azithromycin, a related azalide antibiotic, and digoxin the possibility of raised digoxin levels should be borne in mind. Single mg doses and multiple mg or mg doses of azithromycin had little effect on the plasma pharmacokinetics or urinary excretion of zidovudine or its glucuronide metabolite.
However, administration of azithromycin increased the concentrations of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear cells. The clinical significance of this finding is unclear, but it may be of benefit to patients. Azithromycin does not interact significantly with the hepatic cytochrome P system.
It is not believed to undergo the pharmacokinetic drug interactions as seen with erythromycin and other macrolides. Hepatic cytochrome P induction or inactivation via cytochrome-metabolite complex does not occur with azithromycin. What does Zithromax Azithromycin treat? Zithromax with generic name azithromycin is an antibiotic that is used to treat infections caused by bacteria such as whooping cough, middle ear infection, vaginitis, bronchiectasis, chlamydia, cholera, tonsillitis, bronchitis, pelvic inflammatory disease and numerous others.
Zithromax was the most prescribed antibiotic in the US for outpatients in Pfizer and Pilva signed the licensing agreement in for its manufacturing and distribution. Excretion is biliary, renal at 4. What is Zithromax used for? Zithromax is mainly used as an antibiotic for the treatment of diseases listed above and any others that may be prescribed by a doctor. Zithromax uses also include treatment of skin infections caused by bacteria. It is used for the treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease caused by H.
Tags: boots pharmacy tamiflu topamax bula anvisa augmentin 1000mg pret lamictal lamotrigine prices
© Copyright 2017 Azithromycin 500mg pfizer - healthcoach.training.