Captopril should not be used in animals with known hypersensitivity or allergy to the drug. Captopril may relax blood vessels to such a degree that some animals become weak due to low blood pressure. Less commonly, captopril may affect the blood supply to the kidneys leading to kidney failure. This is most common in dogs and cats treated with higher doses of the drug.

It is also more common in animals with kidney disease and when diuretic drugs such as furosemide are administered. Also, cyclosporine can cause hyperkalemia, and inhibition of angiotensin II leads to reduced aldosterone concentrations, which can increase the serum potassium concentration. Closely monitor renal function and serum potassium concentrations in patients receiving cyclosporine concurrently with ACE inhibitors or potassium salts.

Patients receiving antidiabetic agents can become hypoglycemic if ACE inhibitors i. Moderate ACE inhibitors may enhance the hypoglycemic effects antidiabetic agents by improving insulin sensitivity. Moderate Dexmethylphenidate can reduce the hypotensive effect of antihypertensive agents, including angiotensin-converting enzyme inhibitors ACE inhibitors.

Periodic evaluation of blood pressure is advisable during concurrent use of dexmethylphenidate and antihypertensive agents, particularly during initial coadministration and after dosage increases of dexmethylphenidate. Moderate Quinidine can decrease blood pressure and should be used cautiously in patients receiving antihypertensive agents due to the potential for additive hypotension.

Moderate Additive hypotensive effects can occur with the concomitant administration of diazoxide with other antihypertensive agents. This interaction can be therapeutically advantageous, but dosages must be adjusted accordingly.

The manufacturer advises that IV diazoxide should not be administered to patients within 6 hours of receiving other antihypertensive agents. Major Diethylpropion has vasopressor effects and may limit the benefit of angiotensin-converting enzyme inhibitors. Although leading drug interaction texts differ in the potential for an interaction between diethylpropion and this group of antihypertensive agents, these effects are likely to be clinically significant and have been described in hypertensive patients on these medications.

However, captopril and digoxin are administered together in patients with congestive heart failure. Measure serum digoxin concentrations before initiating captopril. In addition, caution should be exercised when administering digoxin with drugs that may cause a significant deterioration in renal function including angiotensin-converting enzyme inhibitors ACE inhibitors.

A decline in glomerular filtration or tubular secretion may impair the excretion of digoxin. Close monitoring of serum digoxin concentrations is essential to avoid enhanced toxicity. Moderate Drospirenone has antimineralocorticoid effects and may increase serum potassium.

The concurrent use of ACE inhibitors may increase the risk of hyperkalemia, especially in the presence of renal impairment. Monitor serum potassium during the 1st month of drospirenone treatment if an Angiotensin-Converting Enzyme inhibitor ACE inhibitor is used concurrently and thereafter as clinically indicated. Also monitor for any changes in blood pressure, fluid retention, or renal function. Drospirenone; Ethinyl Estradiol; Levomefolate: Moderate Orthostatic hypotension and syncope have been reported during duloxetine administration.

The concurrent administration of antihypertensive agents and duloxetine may increase the risk of hypotension. Monitor blood pressure if the combination is necessary. Moderate Angiotensin-converting enzyme inhibitors ACE inhibitors may enhance the hypoglycemic effects antidiabetic agents, such as empagliflozin, by improving insulin sensitivity.

Moderate ACE inhibitors may enhance the hypoglycemic effects antidiabetic agents, such as linagliptin, by improving insulin sensitivity. Moderate General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Moderate Because entecavir is primarily eliminated by the kidneys and ACE inhibitors can affect renal function, concurrent administration with ACE inhibitors may increase the serum concentrations of entecavir and adverse events.

Monitor for adverse effects when these drugs are coadministered. Major The cardiovascular effects of sympathomimetics, such as ephedrine, may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors. Blood pressure and heart rates should be monitored closely to confirm that the desired antihypertensive effect is achieved. Major Monitor serum potassium and serum creatinine concentrations within 3 to 7 days of initiating coadministration of eplerenone and angiotensin-converting enzyme ACE inhibitors.

Hyperkalemia risk is increased when eplerenone is used with ACE inhibitors. Patients who develop hyperkalemia may continue eplerenone with proper dose adjustment; eplerenone dose reduction decreases potassium concentrations.

Minor Estrogens can induce fluid retention and may increase blood pressure in some patients; patients who are receiving antihypertensive agents concurrently with hormonal contraceptives should be monitored for antihypertensive effectiveness.

Moderate The risk of angioedema, with or without respiratory impairment, may be increased if everolimus is given with other drugs known to cause angioedema such as the angiotensin-converting enzyme inhibitors ACE inhibitors. In a pooled analysis of randomized, double-blind oncology clinical trials, angioedema was reported in 6. If coadministration is necessary, educate patients regarding signs and symptoms of angioedema and monitor therapy closely.

Moderate Patients on angiotensin-converting enzyme inhibitors are at an increased risk of adverse reactions when administered fluorescein injection. If fluorescein injection is deemed necessary in a patient on ACE inhibitor therapy, monitor as appropriate during and after the procedure.

Moderate Olanzapine may induce orthostatic hypotension and thus enhance the effects of antihypertensive agents. Monitor closely for nitritoid reactions during co-therapy with gold and ACE inhibitor agents.

Moderate In general, haloperidol should be used cautiously with antihypertensive agents due to the possibility of additive hypotension. Moderate Hawthorn, Crataegus laevigata also known as C. Following hawthorn administration, the cardiac action potential duration is increased and the refractory period is prolonged.

Hawthorn may also lower peripheral vascular resistance. Patients with hypertension or heart failure should be advised to only use hawthorn with their prescribed medications after discussion with their prescriber. Patients who choose to take hawthorn should receive periodic blood pressure and heart rate monitoring. Moderate Angiotensin-converting enzyme inhibitors decrease aldosterone secretion, leading to small increases in serum potassium levels.

Due to the risk of hyperkalemia, drugs that increase serum potassium concentration, such as potassium-sparing diuretics, potassium salts, and heparin, should be given cautiously, if at all, to patients receiving lisinopril, with frequent serum potassium monitoring. Hyperkalemia can cause serious, sometimes fatal, arrhythmias. Major Spironolactone should not be used concomitantly with ACE inhibitors, especially in the presence of renal impairment renal disease, elderly patients.

Coadministration of ACE inhibitors and spironolactone, even in the presence of a diuretic, has been associated with severe hyperkalemia. Use together with extreme caution and monitor serum potassium concentrations. Major ACE inhibitors can increase the risk of hyperkalemia developing in patients receiving triamterene, especially in the presence of renal impairment.

This combination should be used with caution and serum potassium levels monitored. Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: Minor Although clinical data are lacking, icatibant is a bradykinin B2 receptor antagonist and may theoretically potentiate the antihypertensive effect of ACE inhibitors. Moderate Secondary to alpha-blockade, iloperidone can produce vasodilation that may result in additive effects during concurrent use with antihypertensive agents.

If concurrent use of iloperidone and antihypertensive agents is necessary, patients should be counseled on measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning and rising slowly from a seated position. Moderate Further reductions in blood pressure may occur when inhaled iloprost is administered to patients receiving other antihypertensive agents.

Moderate The effects of indapamide may be additive when administered with other antihypertensive agents or diuretics. In some patients, this may be desirable, but orthostatic hypotension may occur.

Patients with hyponatremia or hypovolemia are more susceptible to developing reversible renal insufficiency when given an angiotensin-converting enzyme inhibitors ACE Inhibitors and diuretic therapy concomitantly. Moderate Monitor patients receiving angiotensin-converting enzyme inhibitors ACE inhibitors concomitantly with insulin for changes in glycemic control. ACE inhibitors may enhance the hypoglycemic effects of insulin by improving insulin sensitivity.

In addition, ACE inhibitors have been associated with a reduced incidence in the development of new-onset diabetes in patients with hypertension or other cardiac disease. Moderate Because the use of other nephrotoxic drugs, including ACE inhibitors, is an additive risk factor for nephrotoxicity in patients receiving radiopaque contrast agents, ACE inhibitor therapy should be withheld, when possible, during radiopaque contrast agent administration.

Keep the bottle tightly closed when not in use. Dosage Information comprehensive What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What should I avoid while taking captopril?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of captopril. Do not use salt substitutes or potassium supplements while taking captopril, unless your doctor has told you to. Take the Captopril tablet marked for the correct day on the blister pack. This will help you remember whether you have taken it.

If you feel better, do not stop taking the tablets. If you stop them, your condition may get worse. The first Ecopace Tablets you take might make you feel dizzy or light-headed. This is because the first dose may make your blood pressure fall by more than doses you take after that.

It may help to lie down until you feel better. If you are concerned talk to your doctor or pharmacist. Your doctor may ask to see you more frequently when you start taking the medicine or when your dose is changed to monitor how you are responding to taking Captopril. You should not skip these visits even if you feel well. Adults with high blood pressure hypertension The usual starting dose is one Standard solution— Dissolve an accurately weighed quantity of USP Captopril Disulfide RS in Mobile phase,and dilute quantitatively,and stepwise if necessary,with Mobile phaseto obtain a solution having a known concentration of about 0.

Test solution— Weigh and finely powder not fewer than 20Tablets. Transfer an accurately weighed portion of the powder,equivalent to about 25mg of captopril,to a suitable centrifuge tube. Use the clear supernatant as the Test solution.

CAPTOPRIL 25MG TABLETS

Moderate General anesthetics can potentiate the hypotensive effects of antihypertensive agents. If you have a sudden onset of severe diarrhea or vomiting or if you sweat a lot, tell your doctor right away. Moderate Tacrolimus, in the absence of overt renal impairment, may adversely affect renal function. Patients taking antihypertensive agents may need to have their therapy modified. Blood pressure and heart rates should be monitored closely to confirm that the desired antihypertensive effect 1mg achieved. Patients receiving antidiabetic agents can become hypoglycemic if ACE inhibitors are administered concomitantly. Lower initial doses of paliperidone may be necessary in patients receiving antihypertensive agents concomitantly. Angioedema involving the tongue, glottis or larynx may be fatal. Presumably captopril to the inhibition of the degradation of endogenous bradykinin, persistent nonproductive cough has been reported with all ACE inhibitors, always resolving after discontinuation of therapy, captopril 1mg. Moderate Captopril may induce orthostatic hypotension and thus enhance the effects of antihypertensive agents. In this case the medicine will normally be started in hospital, and the hospital doctor will decide the best dose for you. Transfer an accurately weighed 1mg of the powder,equivalent to about 25mg of captopril,to a suitable centrifuge tube. Black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks.

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