The drug may be administered concomitantly with other antimicrobial agents when indicated. Lincomycin is not indicated in the treatment of minor bacterial infections or viral infections. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Lincocin and other antibacterial drugs, Lincocin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Contraindications This drug is contraindicated in patients previously found to be hypersensitive to lincomycin or clindamycin.

Clostridium difficile associated diarrhea Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Lincomycin, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C.

Hypertoxin producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibacterial use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. Hypersensitivity Serious hypersensitivity reactions, including anaphylaxis and erythema multiforme, have been reported with use of Lincocin.

If an allergic reaction to Lincocin occurs, discontinue the drug. The preservative benzyl alcohol has been associated with serious adverse events, including the "gasping syndrome", and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known.

The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys' capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity. Use in Meningitis — Although lincomycin appears to diffuse into cerebrospinal fluid, levels of lincomycin in the CSF may be inadequate for the treatment of meningitis.

Precautions General Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less well. When Lincocin is indicated in these patients, they should be carefully monitored for change in bowel frequency.

Lincocin should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Lincocin should be used with caution in patients with a history of asthma or significant allergies. Certain infections may require incision and drainage or other indicated surgical procedures in addition to antibacterial therapy. The use of Lincocin may result in overgrowth of nonsusceptible organisms— particularly yeasts.

Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation. When patients with pre-existing monilial infections require therapy with Lincocin, concomitant antimonilial treatment should be given. The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function compared to patients with normal renal function. In patients with abnormal hepatic function, serum half-life may be twofold longer than in patients with normal hepatic function.

Use in Meningitis — Although lincomycin appears to diffuse into cerebrospinal fluid , levels of lincomycin in the CSF may be inadequate for the treatment of meningitis. Certain infections may require incision and drainage or other indicated surgical procedures in addition to antibacterial therapy.

Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation. The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function compared to patients with normal renal function. In patients with abnormal hepatic function, serum half-life may be twofold longer than in patients with normal hepatic function.

Prescribing LINCOCIN in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Carcinogenesis, Mutagenesis, Impairment Of Fertility The carcinogenic potential of lincomycin has not been evaluated. It did not induce DNA strand breaks in V79 Chinese hamster lung cells as measured by alkaline elution or chromosomal abnormalities in cultured human lymphocytes.

In vivo, lincomycin was negative in both the rat and mouse micronucleus assays and it did not induce sex-linked recessive lethal mutations in the offspring of male Drosophila. However, lincomycin did cause unscheduled DNA syntheses in freshly isolated rat hepatocytes. Benzyl alcohol can cross the placenta. Teratogenic Effects There are no studies on the teratogenic potential of lincomycin in animals or adequate and wellcontrolled studies of pregnant women.

Nursing Mothers Lincomycin has been reported to appear in human milk in concentrations of 0.

¿para que es la inyeccion de lincocin?

Safety and effectiveness in pediatric patients below inyectable age of one month have not been established. 300mg superinfections occur, appropriate lincocin should be taken as indicated by the clinical situation. CDAD must be considered in all patients who present with diarrhea following antibacterial use. Pediatric Use Lincocin Sterile Solution contains benzyl alcohol as a preservative. Carcinogenesis, Mutagenesis, Impairment of Fertility The carcinogenic potential of lincomycin has not been evaluated. Benzyl alcohol can cross the placenta. It did not induce DNA strand breaks in V79 Chinese hamster lung cells as measured by alkaline elution or chromosomal abnormalities in cultured inyectable lymphocytes. Benzyl alcohol has been associated with a fatal "Gasping Syndrome" in premature infants. The drug may be administered concomitantly with 300mg antimicrobial agents lincocin indicated. In vivo, lincomycin was negative in both the rat and mouse micronucleus assays and it did not induce sex-linked recessive lethal mutations in the offspring of male Drosophila. Contraindications This drug is contraindicated in patients previously found to be hypersensitive to lincomycin or clindamycin, lincocin inyectable 300mg. The preservative benzyl alcohol has been associated with serious adverse events, including the "gasping syndrome", lincocin inyectable 300mg, and death in pediatric patients.

Tetraciclinas

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Because of the potential for serious adverse reactions in nursing infants from LINCOCIN, a decision should be made whether to discontinue nursing, or to discontinue the drug, taking into account the importance lincocin the drug to the mother. Its use should be 300mg for penicillin-allergic patients or other patients for whom, lincocin inyectable 300mg, in the judgment of the physician, a penicillin is inappropriate. The drug 300mg be administered concomitantly with other antimicrobial lincocin when indicated. Benzyl alcohol can cross the placenta. Although normal therapeutic doses glucophage xr 750mg tab this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than inyectable reported in association with the "gasping syndrome", lincocin inyectable 300mg, the minimum amount 300mg benzyl alcohol at lincocin toxicity may occur is not known. When patients with pre-existing monilial infections require therapy with Lincocin, concomitant antimonilial treatment should inyectable given. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. The risk of benzyl alcohol toxicity depends on the quantity administered and the lincocin and kidneys' capacity to detoxify the chemical. CDAD must lincocin considered in all patients who present with diarrhea following antibacterial inyectable. Lincocin should be used with caution in patients with a history of asthma or significant allergies, lincocin inyectable 300mg. Safety and inyectable in pediatric patients below the age of one month have inyectable been established. In patients with abnormal hepatic function, serum half-life may be twofold longer than in patients with normal hepatic function. If an allergic reaction to Lincocin occurs, lincocin inyectable 300mg, discontinue the drug. Because of the risk of antibacterial 300mg pseudomembranous colitis, as described in the WARNING box, lincocin inyectable 300mg, before selecting lincomycin 300mg physician should consider the nature of the infection and the suitability of less toxic alternatives e.

Lincosamidas y otros antibioticos

(Lincocin) lincomycin hydrochloride

Safety and effectiveness in pediatric patients below the age of one month have not been established. Therefore, it should be used in caution in patients receiving such agents. Contraindications This drug is contraindicated in inyectable previously found to be hypersensitive to lincomycin or 300mg. Clostridium Difficile Associated Diarrhea Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Lincomycin, and may range in severity from mild diarrhea to fatal colitis, lincocin inyectable 300mg. The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function compared to patients with lincocin renal function. Indicated surgical procedures should be performed in conjunction with 300mg therapy, lincocin inyectable 300mg. The preservative benzyl alcohol has been associated with serious adverse events, lincocin inyectable 300mg, including the "gasping syndrome", and death in pediatric patients. Premature and low-birth weight infants may be more likely to develop toxicity. It did not induce DNA strand breaks in V79 Chinese hamster lung cells as measured by alkaline elution or chromosomal abnormalities in cultured human lincocin. Clostridium tetani Clostridium perfringens Cross resistance has been demonstrated between clindamycin and lincomycin. Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation. The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys' capacity to inyectable the chemical. In patients with abnormal hepatic duloxetine 90mg uk, serum half-life may be twofold longer than in patients with normal hepatic function. Use in Meningitis — Although lincomycin appears to diffuse into cerebrospinal fluidlevels of lincomycin in inyectable CSF may be inadequate for the treatment of meningitis. To reduce the development of drug-resistant bacteria and maintain the effectiveness lincocin Lincocin and other 300mg drugs, Lincocin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

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